Cheap ghd binding websites within the proximal
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 This assumption was based on i the existence of cheap ghd binding websites within the proximal promoters of nearly all hair keratin genes Zhou et al, 1995;Rogers et al, 1998,2000, ii the demonstration the promoter from the pre cortical keratin gene mHa1 may be activated by LEF1/ catenin in epidermal keratinocytes Merill et al, 2001, and iii the visualization of nuclear LEF1 and catenin in mouse pre cortex cells, grouped right into a slender triangle immediately above the apex of the dermal papilla Das Gupta and Fuchs, 1999;Merill et al, 2001. In addition, scientific studies in transgenic mice unveiled the mutation of the LEF1 binding site inside a sort II cortex keratin gene resulted in an obvious reduction of promoter exercise Dunn et al, 1998..

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